INSTRUCTIONS FOR USE RELENZA (ruh-LENS-uh) (zanamivir inhalation powder) for oral inhalation use
Read the Patient Information and this Instructions for Use before you start using RELENZA. Important information: • Be sure to take the dose of RELENZA your healthcare provider has prescribed. • If RELENZA is prescribed for a child, the dose should be given or supervised by an adult who has been instructed on how to use the DISKHALER the right way by a healthcare provider and understands how to use it. • Always check inside the mouthpiece to make sure it is clear before each use. If foreign objects are in the mouthpiece, they could be inhaled and cause serious harm. • Always replace the cover after each use. • Throw away the DISKHALER after treatment is completed. • RELENZA is not in a child-proof container.
Step-by-step instructions for using the DISKHALER:
Step 1: Load the medicine into the DISKHALER.
Figure A	• Start by pulling off the blue cover. See Figure A. • Always check inside the mouthpiece to make sure it is clear before each use. If foreign objects are in the mouthpiece, they could be inhaled and cause serious harm.
Figure B	• Pull the white mouthpiece by the edges to extend the white tray all the way. See Figure B.
Figure C	• Once the white tray is extended all the way, find the raised ridges on each side of it. Press in these ridges, both sides at the same time, and pull the whole white tray out of the DISKHALER body. See Figure C.
Figure D	• Place one silver medicine disk onto the dark brown wheel, flat side up. The four silver blisters on the underside of the medicine disk will drop neatly into the four holes in the wheel. See Figure D.
Figure E	• Push in the white tray as far as it will go. Now the DISKHALER is loaded with medicine. See Figure E.
Step 2: Puncture the blister. The DISKHALER punctures 1 blister of medicine at a time so you can inhale the right amount. It does not matter which blister you start with. Check to make sure that the silver foil is not broken.
Figure F	• Be sure to keep the DISKHALER level so the medicine does not spill out. See Figure F.
Figure G	• Locate the half-circle flap with the name “RELENZA” on top of the DISKHALER. • Lift this flap from the outer edge until it cannot go any farther. Flap must be straight up for the plastic needle to puncture both the top and bottom of the silver medicine disk inside. See Figure G.
Figure H	• Keeping the DISKHALER level, click the flap down into place. See Figure H.
Step 3: Inhale.
Figure I	• Before putting the white mouthpiece into your mouth, breathe all the way out (exhale). See Figure I. Then put the white mouthpiece into your mouth. Be sure to keep the DISKHALER level so the medicine does not spill out. • Close your lips firmly around the mouthpiece. Be sure not to cover the small holes on either side of it. See Figure J. • Breathe in through your mouth steadily and as deeply as you can. Your breath pulls the medicine into your airways and lungs. • Hold your breath for a few seconds to help RELENZA stay in your lungs where it can work.
Figure J
To take another inhalation, move to the next blister by following Step 4 below. After you have inhaled the number of blisters prescribed by your healthcare provider, replace the cover until your next dose.
Step 4: Move the medicine disk to the next blister.
Figure K	• Pull the mouthpiece to extend the white tray, without removing it. See Figure K.
Figure L	• Then push it back until it clicks. This pull-push motion rotates the medicine disk to the next blister. See Figure L. • To take your next inhalation, repeat Steps 2 and 3.
If all 4 blisters in the medicine disk have been used, you are ready to start a new medicine disk (see Step 1). Check to make sure that the silver foil is not broken each time you are ready to puncture the next blister.
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