Calcium Correction for Hypoalbuminemia and Hyperalbuminemia

id

31

full_title

Calcium Correction for Hypoalbuminemia and Hyperalbuminemia

short_title

Ca Correction for Albumin

med_description

Calculates a corrected calcium level for patients with hypoalbuminemia or hyperalbuminemia.

description

The Calcium Correction for Hypoalbuminemia calculates a corrected calcium level for patients with hypoalbuminemia.

keywords

Calcium Correction for Hypoalbuminemia, ca correction, calcium correction, calcium correction calc, calcium calc, hypoalbumin calcium, hypoalbumin ca, hypoalbumin calc, hypoalbuminemia calc, hypoalbuminemia calcium, hypoalbuminemia ca, hypoalbuminemia correction, ca correction, ca level hypoalbuminemia, albumin ca, albumin correct, albumin correct calcium, calcium correction albumin, hyperalbuminemia, ionized calcium

complaint

[ "Abdominal Pain", "AMS", "Weakness" ]

formula

Corrected Calcium = (0.8 * (Normal Albumin - Pt's Albumin)) + Serum Ca Note:formula assumes albumin units ing/dL.

evidence

measurements

[ { "name": "Calcium", "unit": "ca", "error_min": "4", "error_max": "18", "warn_min": "6", "warn_max": "13", "conversion": "0.25", "normal_max_si": "2.625", "normal_max_us": "10.5", "normal_min_si": "2.25", "normal_min_us": "9", "units_si": "mmol/L", "units_us": "mg/dL" }, { "name": "Albumin (General)", "unit": "alb", "error_min": "0", "error_max": "7", "warn_min": "1", "warn_max": "6", "conversion": "10", "normal_max_si": "55", "normal_max_us": "5.5", "normal_min_si": "35", "normal_min_us": "3.5", "units_si": "g/L", "units_us": "g/dL" } ]

information

refrences

{ "Clinical Practice Guidelines": [], "Manufacturer Website": [], "Original/Primary Reference": [ { "href": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1587636/", "text": "Payne RB, Little AJ, Williams RB, Milner JR. Interpretation of Serum Calcium in Patients with Abnormal Serum Proteins. British Medical Journal. 1973;4(5893):643-646" } ], "Other References": [], "Outcomes": [], "Validation": [ { "href": "https://www.ncbi.nlm.nih.gov/pubmed/19654080/", "text": "Parent X, et. al. Corrected calcium: calcium status underestimation in non-hypoalbuminemic patients and in hypercalcemic patients. Ann Biol Clin (Paris). 2009 Jul-Aug;67(4):411-8. doi: 10.1684/abc.2009.0348." } ], "Validations": [] }

pearls

• The total amount of calcium in the serum is found bound to albumin and multiple organic and inorganic anions, while some circulates as ionized or free calcium.

• Changes in albumin can result in a decrease in total calcium (pseudohypocalcemia) or increase in total calcium (pseudohypercalcemia), without changing ionized calcium.

• Rarely, changes in gamma globulins (in multiple myeloma) can result in pseudohypercalcemia.

• Finally, an increase in extracellular pH can result in changes in ionized calcium without changing total calcium.

usecase

• Patients with albumin below the laboratory value of lower limit of normal.

• Patients with albumin above the laboratory value of upper limit of normal.

reasons

Correcting serum calcium levels for levels of albumin outside of the normal range will allow clinicians to: Identify patients whose ionized calcium levels may be out of normal range despite total calcium levels appearing to be within normal range. Identify patients whose ionized calcium levels are likely in normal range while their total calcium levels appear abnormal.

next_advice

Consider measuring ionized calcium to confirm conclusions drawn after correcting for serum calcium.

next_actions

next_management

• If calcium is confirmed to be outside of normal range, consider a diagnostic evaluation to determine the etiology.

Common causes of Hypocalcemia:

• • Vitamin D inadequacy or resistance.

  • Hypoparathyroidism.

  • Renal disease or end-stage liver disease causing vitamin D inadequacy.

  • Malabsorption.

  • Post-gastric bypass surgery.

  • Drugs and toxic ingestions.

  • Hypomagnesemia.

Common Causes of Hypercalcemia:

• • Primary hyperparathyroidism.

  • Vitamin D toxicity.

  • Vitamin A toxicity.

  • Cancer.

  • Sarcoidosis.

  • Medications (e.g. lithium and thiazide diuretics).

  • Dehydration or volume depletion.

  • Genetic conditions (e.g. familial hypocalciuric hypercalcemia).

  • Little or no movement.

diseases

[ "Cancer", "Cirrhosis", "Hepatitis", "Hypocalcemia" ]

instructions

published

2022-04-21T20:29:12.496Z

purpose

[ "Formula" ]

search_terms

[ "lytes", "electrolytes", "albumin", "ca correction", "ca corrected", "hypoalbuminemia", "hyperalbuminemia", "ionized calcium" ]

seo

{ "keywords_en": "Calcium Correction for Hypoalbuminemia, ca correction, calcium correction, calcium correction calc, calcium calc, hypoalbumin calcium, hypoalbumin ca, hypoalbumin calc, hypoalbuminemia calc, hypoalbuminemia calcium, hypoalbuminemia ca, hypoalbuminemia correction, ca correction, ca level hypoalbuminemia, albumin ca, albumin correct, albumin correct calcium, calcium correction albumin, hyperalbuminemia, ionized calcium", "meta_description_en": "The Calcium Correction for Hypoalbuminemia calculates a corrected calcium level for patients with hypoalbuminemia." }

specialty

[ "Cardiology", "Critical Care", "Emergency Medicine", "Endocrinology", "Family Practice", "Geriatrics", "Hematology and Oncology", "Hepatology", "Hospitalist Medicine", "Internal Medicine", "Pediatrics", "Primary Care" ]

departments

[ "Endocrine and Metabolic", "Gastrointestinal", "Renal" ]

tags

[]

version_number

1

versions

[]

related

[ { "calcId": 3311, "short_title_en": "GPS for Cancer Outcomes", "slug": "glasgow-prognostic-score-gps-cancer-outcomes" }, { "calcId": 3312, "short_title_en": "mGPS for Cancer Outcomes", "slug": "modified-glasgow-prognostic-score-mgps-cancer-outcomes" }, { "calcId": 3315, "short_title_en": "Khorana Risk Score for VTE", "slug": "khorana-risk-score-venous-thromboembolism-cancer-patients" } ]

ismed

false

section

[ "whenToUseViewed", "pearlsPitfallsViewed", "whyUseViewed", "nextStepsViewed", "evidenceViewed" ]

cleaned_departments

[ "endocrine", "gastroenterology", "urology" ]

cleaned_use

[ "Patients with albumin below the laboratory value of lower limit of normal.", "Patients with albumin below the laboratory value of lower limit of normal.", "Patients with albumin above the laboratory value of upper limit of normal." ]

pub

true